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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEPDC5
All Species:
6.06
Human Site:
Y1073
Identified Species:
14.81
UniProt:
O75140
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75140
NP_001007189.1
1572
177910
Y1073
S
V
A
M
T
P
T
Y
M
D
S
P
R
K
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852875
773
87442
G292
V
R
L
E
Q
A
E
G
F
P
Q
G
D
N
S
Cat
Felis silvestris
Mouse
Mus musculus
P61460
1527
173129
Y1029
S
V
A
M
T
P
T
Y
V
D
S
P
R
K
A
Rat
Rattus norvegicus
NP_001100699
1456
164725
V974
V
D
Q
T
A
P
L
V
L
D
S
T
S
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517877
828
93963
R347
V
G
V
F
E
V
D
R
L
L
M
I
L
T
K
Chicken
Gallus gallus
XP_415249
1571
177723
T1072
G
S
I
A
I
T
P
T
Y
M
D
S
P
R
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_691450
1590
178752
R1091
A
F
I
L
D
F
I
R
S
P
R
S
S
Y
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728620
1472
168864
G991
S
P
F
R
E
R
V
G
S
N
R
L
P
E
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794020
1608
181354
A1096
C
T
P
L
Q
V
I
A
K
A
M
A
D
P
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7S9J6
2004
222187
Y1249
Q
M
W
Q
K
H
R
Y
I
P
A
S
E
R
S
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
48
N.A.
91.7
87.4
N.A.
49.5
89.1
N.A.
75.5
N.A.
35.7
N.A.
N.A.
32.4
Protein Similarity:
100
N.A.
N.A.
48.6
N.A.
93.8
89.6
N.A.
50.9
94
N.A.
84.5
N.A.
53.7
N.A.
N.A.
48.6
P-Site Identity:
100
N.A.
N.A.
0
N.A.
86.6
20
N.A.
0
0
N.A.
0
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
N.A.
N.A.
0
N.A.
93.3
26.6
N.A.
6.6
6.6
N.A.
20
N.A.
20
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
20
10
10
10
0
10
0
10
10
10
0
0
10
% A
% Cys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
10
0
10
0
0
30
10
0
20
0
0
% D
% Glu:
0
0
0
10
20
0
10
0
0
0
0
0
10
10
0
% E
% Phe:
0
10
10
10
0
10
0
0
10
0
0
0
0
0
0
% F
% Gly:
10
10
0
0
0
0
0
20
0
0
0
10
0
0
10
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
20
0
10
0
20
0
10
0
0
10
0
0
10
% I
% Lys:
0
0
0
0
10
0
0
0
10
0
0
0
0
20
30
% K
% Leu:
0
0
10
20
0
0
10
0
20
10
0
10
10
10
0
% L
% Met:
0
10
0
20
0
0
0
0
10
10
20
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% N
% Pro:
0
10
10
0
0
30
10
0
0
30
0
20
20
10
0
% P
% Gln:
10
0
10
10
20
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
10
0
10
0
10
10
20
0
0
20
0
20
20
0
% R
% Ser:
30
10
0
0
0
0
0
0
20
0
30
30
20
0
30
% S
% Thr:
0
10
0
10
20
10
20
10
0
0
0
10
0
10
0
% T
% Val:
30
20
10
0
0
20
10
10
10
0
0
0
0
0
10
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
30
10
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _